The Furies begins with a prologue, in which a Fury woman and her daughter flee their home in 1646, just ahead of torch-wielding villagers. Alpert then jumps almost 400 years to present day New York. John Rogers is getting a drink in a bar after striking out at a job fair. Across the room, he sees a redheaded woman with great legs. He's surprised when she seems just as interested in him. John thinks its his lucky day when she invites him back to her hotel room in a run down part of Bushwick. Before they can do much more than get naked, John and Ariel are attacked. They manage to escape, but Ariel's bodyguards are killed and Ariel is wounded.
Though he's a former gang member, John fills the role of hero perfectly as he escorts Ariel on a race back to her home in Michigan's Upper Peninsula. Ariel tries to keep her secrets, but more and more of her family's strange history and abilities leak out. We also learn more about the men chasing Ariel. It seems there was a schism in the family. Ariel's half-brother, Sullivan, wants the women's secret to immortality and is willing to use violence, the FBI, and bombs to get what he wants.
The Furies is not so much a science fiction novel as it is a thriller. There are science fiction elements—genetic mutations, drones, caverns filled with laboratories, secret protein formulae, etc.—there are many more thriller elements and tropes here. There are chases (one involving a ferry), numerous gunfights, the aforementioned bombs, and FARC guerrillas. The Furies is an interesting blend of the two genres. I'm not sure I buy the genetic mutations parts of the plot, but that's only because it's on the far-fetched side of science fiction for me. Alpert travels far from his original inspiration to deliver a fast, entertaining read.